MCQ Hematology 11

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A 13-year old girl is referred for cough, chest pain and dyspnea. No adenopathy or hepatosplenomegaly is noted on physical examination. The bone marrow biopsy is normal. The mediastinal biopsy shows a proliferation of large cells with sclerosis and broad bands of fibrosis. Immunohistochemical stains show that the large cells are CD45+, CD19+, CD20+,CD22+, CD10-, CD15-, CD30- and do not express surface immunoglobulins. What is the most likely diagnosis ?

  1. Non-Burkitt small transformed cell lymphoma.
  2. Primary mediastinal large B cell lymphoma
  3. B lymphoblastic lymphoma
  4. Nodular sclerosis Hodgkin disease.
  5. Follicular hyperplasia.
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Category: Hematology MCQs

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