MCQ Hematology Answer 11

Answer: B

Primary mediastinal large B cell lymphomas demonstrate a diffuse large cell proliferation. Sclerosis is present in most cases. The neoplastic cells have a large transformed cell appearance. This type of lymphoma is most common in females and has a proclivity for local invasion and superior vena cava obstruction. The neoplastic cells are CD19, CD20, CD22 positive, they are negative for CD5, CD10, CD30, CD15 and in general do not express surface immunoglobulin. Non-Burkitt small transformed cell lymphomas are positive for CD45, CD19, CD20, CD10 and surface immunoglobulins. B lymphoblastic lymphomas express CD19, CD20, CD10 and do not express surface immunoglobulins. Reed-Sternberg cells are typically CD45-, CD30+ and CD15+.

Follicular hyperplasia is diagnosed morphologically.

Davis, R.E., Dorfman, R.F., Warnke, R.A. Primary large-cell lymphoma of the thymus: a diffuse B-cell neoplasm presenting as primary mediastinal lymphoma. Hum. Pathol, 1990, 21: 1262-1268.

Category: Hematology MCQs