Fibrolamellar Hepatocellular Carcinoma

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Qbase Surgery I: MCQs for the MRCS (Book with CD-ROM)The Correct Answer is A. Usually occurs in children, adolescents, and young adults


  • The fibrolamellar variant of HCC almost always (in approximately 90% of reported cases) occurs in livers without cirrhosis, although 15-20% of the nonfibrolamellar HCCs have also been observed in noncirrhotic livers.
  • Metastatic disease and typical HCC tend to occur predominantly in older patients, and benign lesions, such as adenoma, focal nodular hyperplasia, and fibrolamellar HCC, tend to occur in younger patients.
  • No association with HBV or cirrhosis
  • Better prognosis

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