Liver findings in Primary Biliary Cirrhosis
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The correct Answer is E. None of the aboveAlthough all the features are present in PBC, these are not pathognomic of the condition as they are seen in other diseases of the liver as well.
Liver findings in Primary Biliary Cirrhosis
- Granulomas
- Increased expression of class I MHC on bile duct epithelial cells
- Aberrant expression of class II MHC on bile duct epithelial cells
- T cell infiltrate around the bile ducts – CTL may be early event, but more usual to see CD4+ T cells seen around the bile ducts.
- Excess IgM producing B cells around the bile ducts.
- Features have been said to resemble either (i) graft - versus - host disease; or (ii) transplant rejection.
- (Accumulation of excess copper)
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