Protection Offered by Mucosal Surface of the Stomach

The Correct Answer is A

1. In the bloodstream the pH is about 7.4, while in the mucus gel layer the pH is about 7. In the lumen of the stomach, the pH is very low around 1.5.
2. If any acid in the lumen back diffuses in the mucosal layer, it is quickly buffered by the bicarbonate in the mucus.
3. If you have a situation where you are not making the mucus, or not making enough bicarbonate, then you can have acid back diffusing through the mucus layer. Therefore you can also have pepsin getting through the mucus layer.
4. The mucosal layer leads to a low level of absorption in the stomach, and its integrity is maintained by an adequate blood flow and nutrient supply in order to synthesize a high quality bicarbonate ion.
5. Peptic Ulcer Disease is most likely caused because you have some situation which is disrupting the integrity of the mucosal barrier.

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