MCQ Surgery Answer 22

The Correct Answer is A

The gastrinoma syndrome, or Zollinger-Ellison syndrome, has traditionally been associated with a severe, fulminant ulcer diathesis, often with multiple ulcers, and ulcers in unusual locations such as the post-bulbar region of the duodenum and proximal jejunum.

The vast majority of Zollinger-Ellison syndrome (ZES) patients will develop ulcers, usually in the duodenal bulb, but sometimes also in the postbulbar duodenum or jejunum. An elevated serum gastrin concentration in a patient who is not achlorhydric is pathognomonic of the disease. Secretin testing adds little but may be positive on occasion in the rare patient with only minimally elevated serum gastrin. Extremely elevated serum gastrin levels (>1000 pg/ml) are not diagnostic of ZES as similar elevations do occur in patients who are achlorhydric. Therefore it is generally necessary to document the presence of gastric acid production when evaluating very elevated serum gastrin concentrations with gastric pH measurements or formal gastric analysis.

Category: Surgery MCQs