MCQ Surgery Answer 21
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| Syndrome | Principal Clinical Features | Genetic Abnormality | Probable Disease Mechanism |
| MEN 1 | Hyperplasia or neoplasia of the pituitary gland, parathyroid glands, and endocrine pancreas (3Ps) | MEN1 mutation | Loss of tumor suppressor function |
| MEN IIa | Medullary thyroid cancer, parathyroid hyperplasia, pheochromocytoma (Mnemonic: MePP) | RET oncogene mutation | Persistent activation (gain of function) of growth factor receptor (RET protein) |
| MEN IIb | Medullary thyroid cancer, pheochromocytoma with marfanoid body habitus, and multiple mucosal neuromas | Single, specific RET oncogene mutation (codon 918) found in nearly all patients | Enhance function of intracellular tyrosine kinase domain of growth factor receptor (RET protein) |
| Familial medullary carcinoma of the thyroid | Medullary thyroid cancer | RET oncogene mutation | Similar to MEN 2A. Persistent activation of growth factor receptor (RET protein) |
Tags: MCQ, Surgery, MEN, Multiple Endocrine Neoplasia
Category: Surgery MCQs
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