MCQ Pediatrics Answer 32
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The Philadelphia chromosome is now easily detectable by Southern blot or polymerase chain reaction (PCR) technology. It is nearly always present in chronic myelogenous leukemia (CML), and is one of the best tests to differentiate this condition from other causes of WBC count elevation, especially myelodysplasia, leukemoid reactions, and other leukemias.
Ref:
- Stein JH (ed): Internal Medicine, ed 5. Mosby Inc, 1998, p 1728.
- Fauci AS, Braunwald E, Isselbacher KJ, et al (eds): Harrison’s Principles of Internal Medicine, ed 14. McGraw-Hill, 1998, p 692.
Tags: MCQ, Pediatrics, Philadelphia chromosome
Category: Pediatrics MCQs
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