Albright's hereditary osteodystrophy
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The correct answer is E
Explanation:
The findings of Albright's hereditary osteodystrophy (short stature, brachydactyly, and soft tissue calcification) along with severe hypocalcemia and elevated PTH are diagnostic of pseudohyperparathyroidism (Type IA). This is an autosomal-dominant disorder resulting from a G protein (Gs) defect, which leads to PTH resistance.
Hypothyroidism and ovarian failure are also seen because Gs also couples to TSH and gonadotropin receptor signaling, respectively. Mental retardation is seen in 70% of cases.
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