MCQ Psychiatry Answer 7

The Correct answer is D

Hepatolenticular degeneration, also known as Wilson’s disease, is a copper storage disease. In this disease, copper is stored in the liver resulting in chronic inflammation to the liver and eventually liver failure. Wilson’s disease occurs because of a genetic mutation on chromosome number 13. Therefore, there is a familial history of Wilson’s disease. Wilson’s Disease may present with psychiatric changes including dementia, anxiety, depression, schizophrenia, manic depression, drooling, difficulty speaking and tremor.

Wilson’s disease should be suspected in a young patient who presents with hepatitis or culminant hepatic failure even if Kayser-Fleischer rigs are absent around the eye.

Diagnostic criteria include:
Low serum ceruloplasmin levels (<20 mg%)
High liver copper levels (>250 mg/g) and
high 24 hour urinary copper levels (>100 mg/d or >1.6 mmol/d).

Category: Psychiatry MCQs