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Most children perceived by their parents to have recurrent infections are, in fact, immuno-competent, generally well, and do not have evidence of chronic illness. These children typically are characterized by normal growth and development, superficial bacterial skin infections and predominantly upper respiratory and occasional lower respiratory tract infections due to common viral and bacterial pathogens. They typically have palpable lymph nodes and normal or enlarged tonsils.
Findings on the history and examination, which would suggest the possibility of immunodeficiency, include the following:
- Failure to thrive;
- Severe disease occurring with common viral infections such as chickenpox or measles;
- More than one serious infection, such as meningitis, pneumonia, or bone and joint infection;
- Chronic diarrhea or stools characteristic of malabsorption;
- Repeated infections without intervening periods of good health;
- hronic eczema and alopecia; and
- Frequent fever.
Immunodeficiency is less likely if infections are associated with a strong family history of allergies or contact with many other children in the home or nursery school. AIDS is rapidly becoming the most common severe immunodeficiency disorder, even in children.
Ref: Behrman RE, Kliegman RM, Arvin AM (eds): Nelson Textbook of Pediatrics, ed 15. WB Saunders Co, 1996, pp 916-919.
Tags: MCQ, Pediatrics, Immunodeficiency
Category: Pediatrics MCQs
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