COMEDK 2007 MCQ Answer 47

The correct answer is B

Endoscopic features of Crohn’s disease include: aphthous ulcers, irregular punched-out or longitudinal “serpiginous” ulcers, pseudopolyps, inflammatory polyps, “cobblestone” appearance of the mucosa, strictures, and fistula. Pathologic features of Crohn’s disease (based on biopsy specimens) include many of the same findings as with ulcerative colitis, but the inflammation is transmural, goblet cells and mucin are usually preserved, and granulomas may be present. A granuloma is pathognomonic for Crohn’s disease, but is only present in 50% of cases and its absence does not exclude the diagnosis of Crohn’s disease.

The endoscopic appearance in ulcerative colitis is likened to “wet sandpaper.” Deep, large ulcers (macro-ulceration) of the mucosa may be present in severe ulcerative colitis, but in the majority of people with ulcerative colitis, endoscopically apparent ulcers are usually not seen (in contrast to Crohn’s disease).