MCQ MAHE 2000 Surgery Answer 06

The Correct Answer is A




The preferred method of organ preservation is simple cold storage (CS), which involves flushing the organ with the preservative and storing at 0ºC to 4ºC prior to transplantation.The preferred organ preservation solution varies between transplant centers.

In the 1970s, Collins developed a preservation solution later modified in Europe (EuroCollins solution, (EC)), which became the standard for CS of kidneys. This solution was a phosphate-buffered saccharide solution and the high concentration of glucose-suppressed hypothermic-induced cell swelling, which made these solutions suitable for 24 to 30-hour preservation of kidneys. For the liver and pancreas, the safe preservation time was less (four to eight hours).

During the same decade, a hypertonic solution was developed by Marshall that contained citrate as an agent to suppress hypothermic-induced cell swelling. This solution was also successful in kidney preservation for approximately 30 hours and in liver preservation for up to approximately eight hours.

Currently,UW solution continues to be the gold standard for organ preservation; however, two other solutions, Celsior and histidine-tryptophan-ketoglutarate (HTK), claim equivalency based upon laboratory and clinical studies. Celsior is a modified UW solution that takes advantage of the primary agent in UW that makes it a superior preservation solution – lactobionic acid. It is therefore not surprising that Celsior should provide similar preservation efficacy to UW solution; however, Celsior has not been tested for long-term (48 to 72 hour) preservation in renal, pancreas, or liver transplant models.

Category: MAHE 2000 MCQs