Drug Induced Liver Injury
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The Correct Answer is D
Hepatotoxicity in Patients with Chronic Liver Disease
- Patients with liver disease are not uniformly at increased risk for hepatic injury due to
- Diminished likelihood of toxic reactions as a result of decreased enzyme activity.
- Rates of drug metabolism in patients with cirrhosis may be reduced as much as 50 %.
- Changes resulting from the increased fibrosis along the hepatic sinusoids in patients with cirrhosis further separate the bloodstream and hepatocyte.
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