Systemic Lupus Erythematosus
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- Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by production of autoantibodies to parts of the cell nucleus.
- Cardiac complications include pericarditis, endocarditis (heart murmurs and valvular damage secondary to Libman-Sacks vegetations on the mitral valve), and coronary artery disease (CAD). 50% of SLE patients have endothelial damage to their heart valves
- Endocarditis in the form of nonbacterial vegetations (Libman Sacks nodules) vary from mild valvular thickening (common but with little or no functional problems) to large vegetations affecting the function of the valve
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