Endocrinology MCQ Answer 035

Answer D

Heterosexual precocity (virilization in girls, feminization in boys)

1. ovarian tumours
2. adrenal tumours
3. congenital adrenal hyperplasia (21 OH deficiency)

• congenital adrenal hyperplasia
• 21 hydroxylase deficiency (most common)
• simple virilizing

→ pseudohermaphroditism (female with virilized external genitals)

→ fused labia, large clitoris

→ ↑ progesterone, ↑ 17-OH progesterone, ↑ androgen

• salt wasting

→ impaired aldosterone secretion (↓Na, ↑K)

• 11 hydroxylase deficiency (rare)
• virilization + salt retention (mineralocorticoid activity)

• androgen insensitivity syndrome (testicular feminization)
• 46,XY genotype with ♀ phenotype:
• defective androgen receptor
• blind end vagina, testes are present (must be removed at puberty to prevent cancer)

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