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The Correct Option is
C
Phenoxybenzamine binds covalently to the alpha receptor, thereby producing an irreversible (insurmountable) blockade. The other agents are competitive pharmacologic antagonists - ie, their effects can be surmounted by increased concentrations of agonist. This difference may be important in the treatment of pheochromocytoma, because massive releases of catecholamines from the tumor may overcome a reversible blockade.
Category:
Pharmacology MCQs
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