Answer to Pharmacology MCQ 465
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1. 90-98% of ethanol ingested is completely oxidized in the body. The rest is excreted via the urine and expired air.
2. At BAC > .01% the metabolism of ethanol follows zero-order kinetics.
Originally it was postulated that alcohol elimination obeys zero-order kinetics, i.e. is independent of the blood concentration above about 0.1 mg/ml. There is substantial evidence now that Michaelis-Menten kinetics more accurately describe the situation. The maximum reaction rate (Vm) and Michaelis-Menten constant (Km) for the average man are approximately 25 mg/100 ml/hour and 10.5 mg/100 ml, respectively.
Category: Pharmacology MCQs
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