Pharmacology MCQ 486
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In acidic urine (pH 6.0) the antimalarial drug pyrimethamine (pK 7.0) would(Note: antilog (1) = 10; antilog (-1) = .1)
A. exist in the protonated form at a ratio of 10:1 and thus is in the poorly lipid soluble form.
B. exist in the unprotonated form at a ratio of 10:1 and thus would be highly lipid soluble.
C. charged and uncharged forms of the drug are at a steady-state equilibrium.
D. the drug is charged at all body biophase pH's.
E. none of the above because this drug is a weak acid.
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Category: Pharmacology MCQs
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