A drug that is a weak base (pKa = 8.5) enters the tubular urine (pH 6.4). Thus, the drug now
A. exists predominantly in its protonated form, which favors reabsorption into plasma.
B. exists predominantly in its protonated form, which does not favor reabsorption into plasma.

C. exists predominantly in its nonprotonated form, wh

ich favors reabsorption into plasma
D. exists predominantly in its nonprotonated form, which does not favor reabsorption into plasma.
E. displays a prominent first-pass effect.
Answer
Category:
Pharmacology MCQs
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