MCQ Pathology 18

You are a junior pathologist, first week as an attending, and receive a biopsy labeled “nasopharyngeal mass”. Histologic examination reveals an overwhelming number of small dark cells diffusely distributed with vague nests and scattered single large oval cells with relatively abundant cytoplasm. You believe this lesion represents a type III undifferentiated nasopharyngeal carcinoma. Which immunophenotype would best support your belief?


1.positive Leukocyte Common Antigen (LCA- lymphoid cell marker) in both small and large cells.
2.positive Cytokeratin (CK- epithelial cell marker) in the small dark blue cell population only.
3.positive EBV (Epstein-Barr virus genomic DNA marker) in the small dark blue cell population only.
4.Positive Cytokeratin (CK- epithelial cell marker) and EBV (Epstein-Barr virus genomic DNA marker) in the large oval cells.
5.positive Leukocyte Common Antigen (LCA- lymphoid cell marker) in the small dark blue cells and no staining of the large oval cells with cytokeratin (CK- epithelial cell marker).

Answer

Tags: MCQ, Pathology, Nasopharyngeal Cancer

Category: Pathology MCQs