AIIMS Nov 2006 - Pre Clinical
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Pathology
28) NK cells acts on virus infected cells which are
a. which express MHC -1
b. which doent express MHC -1
C. which express MHC - 2
d. which doesnot express MHC - 2
29)in acute inflammation endothelial cells retractions causes
a. immediate transient increse in permeability
b. immediate prolonged increase in permeability
c. late transient increase in permeability
d. late prolonged increase in permeability
30)the mechanisms of phagocytosis of bacteria infected cells by NK cells is
a. peforin?
b.
c.
d.
31) Two different germ cell liver presented in a single individual from 2/more zygotes
a. Chimerism
b. Mosaicism
c. Segregation
d.
a. which express MHC -1
b. which doent express MHC -1
C. which express MHC - 2
d. which doesnot express MHC - 2
29)in acute inflammation endothelial cells retractions causes
a. immediate transient increse in permeability
b. immediate prolonged increase in permeability
c. late transient increase in permeability
d. late prolonged increase in permeability
30)the mechanisms of phagocytosis of bacteria infected cells by NK cells is
a. peforin?
b.
c.
d.
31) Two different germ cell liver presented in a single individual from 2/more zygotes
a. Chimerism
b. Mosaicism
c. Segregation
d.
32) Which gene mutation is least likely to be associated with breast cancer:
- Li-Fraumenni syndrome
- Ataxia Telengiectasia
- BRCA1
- BRCA 2
33. In fetal & embryonic cells, dinision uninhibited, in adults cells not seen:
a. Infetal cells, protease absent for degrading cyclin DK
b. In adult cells (-) of cyclins DK present entering into S phase
c.
d.
34. Amyloid β pleated sheet is confirmed by
a. Scanning electron microscopy
b. x-ray crystallography
c. Apple green florescence in congo red staining
d. Polarizing electron microscope
35. AML poor prognosis associated
a. Monosomy 7
b. Inv. 16
c. t (8, 21)
d. CELLS with normal genotype
36. C- C chemokines is:
a. Eotaxin,
b. ILE
c.
d.
37. Steroid resistant NS associated with which gene
a. NPHSI
b. PAX
c. HOX II
38. Collagen type IV &alpha5 chain helps in
a. Thin basement membrane disease
b. Alport syndrome
c.
39. Acid phosphatase stains
a. Monocyte
b. B Lymphocyte
c. T Lymphocyte
d. Myelocyte
40. Pancytopemia with bone marrow cellularity all except:
a. G6PD def.
b. Myelodysplasia
c. PNH
d. Megaloblastic anemia
a. Infetal cells, protease absent for degrading cyclin DK
b. In adult cells (-) of cyclins DK present entering into S phase
c.
d.
34. Amyloid β pleated sheet is confirmed by
a. Scanning electron microscopy
b. x-ray crystallography
c. Apple green florescence in congo red staining
d. Polarizing electron microscope
35. AML poor prognosis associated
a. Monosomy 7
b. Inv. 16
c. t (8, 21)
d. CELLS with normal genotype
36. C- C chemokines is:
a. Eotaxin,
b. ILE
c.
d.
37. Steroid resistant NS associated with which gene
a. NPHSI
b. PAX
c. HOX II
38. Collagen type IV &alpha5 chain helps in
a. Thin basement membrane disease
b. Alport syndrome
c.
39. Acid phosphatase stains
a. Monocyte
b. B Lymphocyte
c. T Lymphocyte
d. Myelocyte
40. Pancytopemia with bone marrow cellularity all except:
a. G6PD def.
b. Myelodysplasia
c. PNH
d. Megaloblastic anemia
41. Most common lymphoproliferative disease in post transplant patients involves:
- B CELLS
- T CELLS
- NK CELLS
- NULL CELLS
42. Cystosolic cytochrome – c is used in elution chain
a. Necrosis
b. Apoplosis
43. Cy br green dye in used for:
a. HLDR
b. Immunofluorescent
b. PCR
d. ELISA
44. Antiapoptotic gene is:
a. BAX
b. BAD
c. BCL – XL
45. Poor prognostic marker of AML
a. Inv (16)
b. t ( 8 : 21)
c. t (15:17)
d. inv (3)
46. “Rheumatoid Factor” is of following type –
a. IgM
b. IgG
c. IgA
47. True regarding beta plated sheets of a myloid-
a. Stained by congo red & gives +ve birefringence on polariased light
b. Stained by olired – o
48. Breast cancer is least commonly associated with –
a. BRCA – I
b. BRCA – II
c. Her – 2 – nec.
d. P – 53
49. Which of following pigments are involved in free radical injury
a. Lipofuscin
b. Melamin
c. Prilirubin
d. Hematin
Microbiology
50) a patient presented with cough with expectoration sputum culture shows gram negative organisms from only charcol extract agar, the organism is
a. listeria monocytogens
b. M. catarrhalis
c. B. malli/psudomalli
d. legionella
51. Pustule an back of hand ulcer discharge staining
a. polychrome methylene blue
b. Modified Kinyoun stain
c. Pas
d.
52. A patient admitted to an ICU is on central venous line for the last one week. He is on ceftazidime and amikacin. After 7 days of antibiotics he develops a spike of fever an his blood culture is positive for gram positive cocci in chains, which are catalase negative. Following this, vancomycin was started but the culture remained positive for the same organism even after 2 weeks of therapy. The most likely organism causing infection is:
a. Staphylococcus aureus
b. Viridans streptococci
c. Enterococcus faecalis
d. Coagulase negative staphylococcus
53. With reference to bacterioides fragilis the following statements are true, except:
a. B. fragilis is the same frequent anaerobe isolated from clinical samples
b. B. fragilis is not uniformaly sensitive to metronidazole
c. The lipopolysaccharide formed by B. fragilis is structurally and functionally different from the conventional endotoxin
d. Shock and disseminated intravascular coagulation are common in bacteroides bacteremia
54. Pus cells true but organism absent on grams stain is:
a. Chlamydia
b. Gonorrhoea
c.
d.
55. True is
a. agar for nutrition
b. Nutrient broth basal
c. Choc. Gas is selective
d. When selective agent added to solidmed enrichment
56. Fungus is biopsy stain is:
a. Maner
b. Alzarian red
c. Pas
d. Polychrome methylen blue
57. Which bacteria acts by mechanism of CAMP antivation
Ans: V. cholerae
58. Young man, uretheral discharge which has no organism but only pus cells. Diagnosis should be done on:
a. Thiragen martin
b. Mc coy cell
59.Alpha hemolytic streptococcus URTI, to prove:
a. Bacitracin sensitivity
b. Optochin sensitivity
c. Bile solubility
d. Catalase positivity
60. Fungus is biopsy, stain is:
a. Polychrome methylene blue
b. PAS
c. Alzarin red
d. Manson
61. Acid phosphatase stains
a. Monocyte
b. beta lymphocytic
c. T lymphocyte
d. Myelocyte
Pharmacology
a. Necrosis
b. Apoplosis
43. Cy br green dye in used for:
a. HLDR
b. Immunofluorescent
b. PCR
d. ELISA
44. Antiapoptotic gene is:
a. BAX
b. BAD
c. BCL – XL
45. Poor prognostic marker of AML
a. Inv (16)
b. t ( 8 : 21)
c. t (15:17)
d. inv (3)
46. “Rheumatoid Factor” is of following type –
a. IgM
b. IgG
c. IgA
47. True regarding beta plated sheets of a myloid-
a. Stained by congo red & gives +ve birefringence on polariased light
b. Stained by olired – o
48. Breast cancer is least commonly associated with –
a. BRCA – I
b. BRCA – II
c. Her – 2 – nec.
d. P – 53
49. Which of following pigments are involved in free radical injury
a. Lipofuscin
b. Melamin
c. Prilirubin
d. Hematin
Microbiology
50) a patient presented with cough with expectoration sputum culture shows gram negative organisms from only charcol extract agar, the organism is
a. listeria monocytogens
b. M. catarrhalis
c. B. malli/psudomalli
d. legionella
51. Pustule an back of hand ulcer discharge staining
a. polychrome methylene blue
b. Modified Kinyoun stain
c. Pas
d.
52. A patient admitted to an ICU is on central venous line for the last one week. He is on ceftazidime and amikacin. After 7 days of antibiotics he develops a spike of fever an his blood culture is positive for gram positive cocci in chains, which are catalase negative. Following this, vancomycin was started but the culture remained positive for the same organism even after 2 weeks of therapy. The most likely organism causing infection is:
a. Staphylococcus aureus
b. Viridans streptococci
c. Enterococcus faecalis
d. Coagulase negative staphylococcus
53. With reference to bacterioides fragilis the following statements are true, except:
a. B. fragilis is the same frequent anaerobe isolated from clinical samples
b. B. fragilis is not uniformaly sensitive to metronidazole
c. The lipopolysaccharide formed by B. fragilis is structurally and functionally different from the conventional endotoxin
d. Shock and disseminated intravascular coagulation are common in bacteroides bacteremia
54. Pus cells true but organism absent on grams stain is:
a. Chlamydia
b. Gonorrhoea
c.
d.
55. True is
a. agar for nutrition
b. Nutrient broth basal
c. Choc. Gas is selective
d. When selective agent added to solidmed enrichment
56. Fungus is biopsy stain is:
a. Maner
b. Alzarian red
c. Pas
d. Polychrome methylen blue
57. Which bacteria acts by mechanism of CAMP antivation
Ans: V. cholerae
58. Young man, uretheral discharge which has no organism but only pus cells. Diagnosis should be done on:
a. Thiragen martin
b. Mc coy cell
59.Alpha hemolytic streptococcus URTI, to prove:
a. Bacitracin sensitivity
b. Optochin sensitivity
c. Bile solubility
d. Catalase positivity
60. Fungus is biopsy, stain is:
a. Polychrome methylene blue
b. PAS
c. Alzarin red
d. Manson
61. Acid phosphatase stains
a. Monocyte
b. beta lymphocytic
c. T lymphocyte
d. Myelocyte
Pharmacology
62)which is not a second generation H-1 antagonist
a. acrivastatin
b. loratidin
c. fexofenadine
d. cyclizine
63. H. Pylori Rx all except:
a. Amoxicillin
b. Omeprazole
c. Metronidazole
d. Mosapride
64. Long acting beta agonist
a. Orciprenaline
b. Salmeterol
c. ……… terol
d.
65. Prodrug is
a. Enalapril
b.
c.
d.
66. Which drug act on Cell wall
a. Cefepime
b. Erythromycin
c. Tetracycline
d. Lomefloxacin
67. In HIV with pregnancy which drug is given to treat a fetus developing HIV following transmission from mother?
a. Lamivudine
b. Starudine
c. Nevirapine
d.
68. Transient amneria loss of memory
a. Ethionamide
b. Z
c. H
d. R
69. Class Ic antiarrhythmic
a. Encainide
b. Tocainide
c. Propafename
d. Flecainide
70. Acetycation is mechanism for all except:
a. INH
b. Procainamide
c. Dapsone
d. Me tochlopramde
71. Loading dose depends on:
a. Ronte of aden
b. Clearance
c. Volume of distribution
d. t ½
72. Doc in multiple sclerosis
a. IFN alpha
b. IFN beta
c. IFN gamma
d. Intiliximab
73. Creatimine clearance < 10 mg%, which is not given
a. Amikacin
b. Rifampicin
c. Vancomycin
d. Amphotericin
74. Drug for long term maintenance of morphine with drawl
a. Methadone
75. Benzodiazepnic antagonist
a. Flumazenil
76. Which ATT not given in pregnancy:
a. S
b. H
c. Z
d. R
77. Enterohepatic circulation occur with which NSAID
a. Aspirin
b. Phemylbutazone
c. Proxicam
d. Ibuprefem
78. Which of the following NSAID is metabolized leg liver:
a. Aspirin
b. Pheyl Butazone
c. Ibuprofen
d. Piroxicam
Forensic
79. Sexual asphyxia is seen in cases of
- Masochism
- Voyeurism
- Sadism
- Fetichism
80. Chills & rigors like malaria occurs in which poisoning
a. Arsenic
b. Red P
c. Mg
d. Hg
81. Mechanism of “criminal abortion” –
a. Infection & inflame action of endometrium
b. uterine contraction
c. Placental separation
d. Stimulation of nerve
82. The “Knot” in judicial hanging is placed at:-
a. The back of the neck
b. The side of the neck
c. Below the chin
d.
a. Arsenic
b. Red P
c. Mg
d. Hg
81. Mechanism of “criminal abortion” –
a. Infection & inflame action of endometrium
b. uterine contraction
c. Placental separation
d. Stimulation of nerve
82. The “Knot” in judicial hanging is placed at:-
a. The back of the neck
b. The side of the neck
c. Below the chin
d.
Category: AIIMS Nov 2006 MCQs
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