Zollinger-Ellison syndrome is caused by excessive gastrin production

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Mayo Clinic Gastroenterology and Hepatology Board ReviewThe correct answer is C
Explanation

Zollinger-Ellison syndrome is caused by excessive gastrin production and is usually due to a gastrinoma (90%)of the pancreas.The diagnosis should be suspected in the case of peptic ulcers failing to respond to drug therapy and repeated episodes of diarrhea and steathorrea (as in this case) Antral G cell hyperplasia is present in 10%. The commonest location is the duodenal bulb, followed by the stomach and then the postbulbar dusodenum. Gastro-esophageal reflux (as in this case)is a complication rather than a cause and is present in most of these patients and often complicated by esophagitis.

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