Predictors of Severity of Acute Pancreatitis

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The Correct Answer is C. Serum Amylase > 3x the upper limit of normal


Crush Step 2: The Ultimate USMLE Step 2 ReviewPredictors of Severity of Acute Pancreatitis

  • Clinical signs: peritonitis, shock, respiratory distress
  • Ranson’s signs: 11 signs that include prognostic significance during the 1st 48 hours. A higher score means more severe disease.
  • APACHE-II: sensitive and specific, can be calculated on admission

Ranson’s Criteria

On Admission

  • Age > 55 years
  • WBC > 16,000/mm3
  • Blood Glucose > 200 mg/dl
  • LDH > 350 IU/ L
  • AST > 250 U/L

During the first 48 Hours

  • Fall in Heamatocrit > 10%
  • Serum Calcium <>
  • Base deficit > 4m Eq/L
  • Fluid Sequestration > 6 L
  • BUN rises > 5mg/dl
  • PaO2 <>
Risk of morbidity and mortality depends on patient’s score at 28 Hours


  • Number of signs 0-2 3-4 5-6 7-8
  • Percent mortality 0.9 16 40 100
  • Percent morbidity 3.7 40 93 100
  • > 7Days in the ICU

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