Autoimmune pancreatitis

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The Correct answer is B

Autoimmune pancreatitis is a type of chronic pancreatitis characterized by an autoimmune inflammatory process in which lymphocyte infiltration with associated fibrosis of the pancreas causes organ dysfunction.

Patients with autoimmune pancreatitis present with a wide variety of symptoms, but severe abdominal pain or acute pancreatitis is unusual.
Usmle Step 1 (Rapid Review Series)
Autoimmune pancreatitis
  • an inflammatory process centered around the large pancreatic ducts
  • presents as a pancreatic mass or diffuse swelling that mimics pancreatic cancer
  • can also cause biliary strictures, mimicking PSC (primary sclerosing cholangitis)
  • may affect other organs such as the lung or kidney
  • imaging: on CT, pancreas is diffusely, abnormally enlarged
  • microscopically, there are numerous plasma cells and lymphocytes around pancreatic ducts
  • hallmark feature: IgG subtype 4 is elevated
  • imaging: on ERCP, very narrowed pancreatic duct
  • this is clinically important because treatment is simply medical (steroids) and the disease can be confused with cancer

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