MCQ Pathology Answer 42

• Hashimoto thyroiditis : Anti-thyroglobulin, antimicrosomal antibodies, associated with anti-TSH.
• Autoimmune hemolytic anemia: IgG autoantibodies (warm antibody), IgM antibody (cold agglutinin disease).
• Autoimmune atrophic gastritis of pernicious anemia: Anti-parietal cell antibodies.
• Goodpasture syndrome: Anti-glomerular basement membrane antibodies.
• Autoimmune thrombocytopenia:
• Insulin-dependant DM: Islet cell destruction due to: genetic susceptibility, autoimmunity, environmental insult.
• Myasthenia gravis: autoantibodies to acetylcholine receptors.
• Graves disease: TSI, TGI, can have antimicrosomal antibodies.

• Primary biliary cirrhosis: AMA (antimitochondrial antibody).
• Autoimmune hepatitis: Type I: anti-smooth muscle, Type II: anti-LKM1, Type III: antibody against soluble liver antigen (cytokeratin).
• Ulcerative Colitis: ANCA (anti-neutrophil) antibody.

• SLE: ANA (anti nuclear antibodies). Anti-ds DNA and Anti-sm are diagnostic for SLE.
• Rheumatoid Arthritis: 80% have +rheumatoid factor (anti-IgG antibody).
• Sjogren syndrome: SS-A, SS-B autoantibodies present in 70% of cases.

• Inflammatory myopathies (myositis—dermatomyositis/polymyositis): Anti-Jo-1, Anti-Mi-2.
• Systemic Sclerosis (Scleroderma): Limited (CREST)-Anti-centromere. Diffuse-Anti-topoisome. I, Anti-Scl-70.
• Polyarteritis nodosa: pANCA.

Category: Pathology MCQs