MCQ Pathology Answer 23
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Desquamative Interstitial Pneumonia (DIP)
Prominent aggregation of alveolar macrophages w/in the alveoli and little or no fibrosis. Process is all through lung. Bland infiltrates.
Clinical:
- Slow development of cough and dyspnea à to marked respiratory distress, cyanosis and clubbing of the fingers.
- CXR: Ground glass infiltrates in bilateral lower lobe. Diffuse haziness.
- 90% are smokers.
Pathology:
- Little interstitial infiltrate/primarily intra-alveolar components.
- Minimal fibrosis
- Accumulation in airspaces of ↑ # of macrophages w/lipid and PAS (+) granules. Alveolar septa are thickened by sparse inflammatory cell infiltrates.
- Walls of alveoli are still intact.
- Homogeneous pattern.
- Stop smoking.
- Good response to steroids but some may progress to interstitial fibrosis and honeycombing.
Category: Pathology MCQs
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