Atopic Dermatitis
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The Correct Answer is B(Harrison’s 16th Ed., 288)
Clinical features of Atopic Dermatitis are:
· Pruritus and scratching
· Course marked by exacerbations and remissions
· Lesions typical of eczematous dermatitis
· Personal or family history of atopy
· Clinical course lasting longer than 6 weeks
Patients with AD may display a variety of immunoregulatory abnormalities:
· Increased IgE synthesis
· Increased serum IgE
· Increased specific IgE to foods, aeroallergens, bacteria and bacterial products
· Increased expression of CD 23 (low affinity IgE receptor) on monocytes and B-cells
· Impaired delayed type hypersensitivity reactions.
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