MCQ Hematology Answer 32
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The dose of platelets should be individualized. A number of simple rules can be used to calculate the appropriate dose.
- A dose of 1 random donor platelet concentrate per 10 kg body weight can be expected to increase the platelet count by 5000/uL in a non-refractory patient.
- One random donor platelet concentrate is expected to increase the platelet count by 5000 to 10,000/uL in a 70 kg patient who is not refractory.
- Generally, a pool of 6 to 8 platelet concentrates or a single apheresis unit is sufficient to correct or prevent bleeding in a normal sized adult weighing up to 90 kg.
- One apheresis product is equivalent to 6 to 8 random donor platelet concentrates and therefore should increase the platelet count by 30,000/uL to 40,000/uL in a 70 kg patient.
- For pediatric patients, 5 mL/kg body weight of a random donor platelet concentrate should increase the platelet count by 5000/uL. A single platelet concentrate contains about 45 to 50 mL and should supply the needs of patients up to 8 kg. If the entire platelet concentrate is not used for a given patient, it is not practical to salvage the remainder of the unit.
- For children >8 kg, a standard dose of 1 unit/10 kg should be used.
- In the absence of increased platelet destruction, platelet transfusion will usually need to be repeated every 3-5 days.
- If increased platelet destruction or consumption is present, daily administration may be required.
Tags: MCQ, Hematology, Platelet Transfusion
Category: Hematology MCQs
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