NSAID risk of ulcer disease
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Although considered a risk factor in the past, several studies showed that emotional stress is not a risk factor for the development of duodenal ulcer. Daily NSAID use significantly increases the risk of ulcer disease (risk ratio, 10- to 20-fold). Gastric infection with H. pylori increases risk about five- to sevenfold. Cigarette smoking doubles the risk of duodenal ulcer. At least 90% of those patients with Zollinger-Ellison syndrome have duodenal ulcer.
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