Breast Histology

- Terminal duct lobular unit (TDLU)

- consists lobule and smaller terminal ductules

- together empty into the segmental duct, then the lactiferous sinus, then the collecting duct

- Large collecting ducts

- Most of the breast stroma consists a loose connective tissue, adipose tissue, elastic fibers that support the larger ducts (interlobular stroma)

- However each lobule is surrounded by the intralobular stroma (hormonal responsive stroma)

- Blood supply of the breast is predominantly from the internal mammary artery and lateral thoracic artery

- Lymphatic drainage is a valveless unidirectional flow from superficial to deep

- Majority of lymphatic drainage is to axillary nodes, 97%

- 3% going to internal mammary chain

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