Nonsense Mutation

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The Human CellThe Correct Answer is B

With a nonsense mutation, the new nucleotide changes a codon that specified an amino acid to one of the STOP codons (TAA, TAG, or TGA). Therefore, translation of the messenger RNA transcribed from this mutant gene will stop prematurely. The earlier in the gene that this occurs, the more truncated the protein product and the more likely that it will be unable to function.

With a missense mutation, the new nucleotide alters the codon so as to produce an altered amino acid in the protein product.


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