HNPCC Colon Cancer
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The Correct Answer is AHistory is most consistent with HNPCC
HNPCC is linked to mutations caused by microsatellite instability in several mismatch repair genes, notably hMSH2 & hMLH1. As a result, there is defect repair of DNA mismatches with abnormal cell growth & tumour development. The majority of these mutations are inactivating insertions or deletions.
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