H2 antihistamines and Allergies
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H2 antihistamines, such as cimetidine, famotidine, and ranitidine, may have a role when used in combination with H1 antihistamines in selected instances of urticaria. H1 and H2 antihistamines are thought to have a synergistic effect and often result in a more rapid and complete resolution of urticaria than H1 antihistamines alone, especially if given simultaneously intravenously.
Commonly used first-generation agents include diphenhydramine, hydroxyzine, doxepin, chlorpheniramine, and cyproheptadine. The second-generation agents that are currently available in the United States are cetirizine, desloratadine, loratadine, and fexofenadine. All 4 are active in chronic urticaria.
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