Anti-SSB
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Anti-SSB (or Anti-La)
The specificity of antibodies to Ro (SS-A) and La (SS-B) in Sjogren's syndrome (SS) has been studied by counterimmunoelectrophoresis and immunodiffusion.
Anti-Ro was found in 56% and anti-La in 42% of patients with SS and in 38% and 6% respectively in SLE. Anti-La was rare (less than 1%) in other connective tissue diseases.
These data confirm that anti-La, but not anti-Ro, has a high diagnostic specificity for Sjogren's syndrome and merits inclusion as separate diagnostic criterion for the disease.
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