COMEDK 2007 MCQ Answer 65
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The correct answer is B
A drug normally used to fight tuberculosis, isoniazid (INH) with pyridoxine, is also helpful in controlling severe gross tremors which are posture related. Unfortunately, large doses of isoniazid are needed to be effective, and this can result in liver toxicity. Given the danger, this medication should only be used in extreme cases, and liver function must be evaluated regularly.
Four patients with disabling action tremor in the setting of MS were treated with isoniazid (800 to 1200 mg per day). All patients showed significant improvement of the tremor, allowing more functional use of their extremities. To the best of our knowledge, this is the only medical treatment for this type of tremor.
Ref: Treatment of action tremor in multiple sclerosis with isoniazid;A. F. Sabra, M. Hallett, L. Sudarsky and W. Mullally ; American Academy of Neurology ;NEUROLOGY 1982;32:912
A drug normally used to fight tuberculosis, isoniazid (INH) with pyridoxine, is also helpful in controlling severe gross tremors which are posture related. Unfortunately, large doses of isoniazid are needed to be effective, and this can result in liver toxicity. Given the danger, this medication should only be used in extreme cases, and liver function must be evaluated regularly.
Four patients with disabling action tremor in the setting of MS were treated with isoniazid (800 to 1200 mg per day). All patients showed significant improvement of the tremor, allowing more functional use of their extremities. To the best of our knowledge, this is the only medical treatment for this type of tremor.
Ref: Treatment of action tremor in multiple sclerosis with isoniazid;A. F. Sabra, M. Hallett, L. Sudarsky and W. Mullally ; American Academy of Neurology ;NEUROLOGY 1982;32:912
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