COMEDK 2007 MCQ Answer 60
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The correct answer is A
Goodpasture syndrome (antiglomerular basement membrane disease)
Goodpasture syndrome (antiglomerular basement membrane disease)
Ña. The cause is antibodies (antiglomerular basement membrane antibodies) directed against antigens in glomerular and pulmonary alveolar basement membranes.
Ñb. Fluorescent antibody studies for IgG demonstrate linear immunofluorescence.
c. Clinical manifestations include:
Ñ(1) Nephritic syndrome
Ñ(2) Pneumonitis with hemoptysis (hemorrhagic pneumonitis)
(3) Peak incidence in men in their mid-20s
(4) RPGN crescentic morphology with linear immunofluorescence
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