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CLike all antiarrhythmic drugs, amiodarone can aggravate arrhythmia; this is reported in 3% to 5% of patients.However, because of the long time course of drug action, it may be difficult to distinguish between the natural history of the underlying cardiac disease and the arrhythmia and a drug-related aggravation of arrhythmia. Although amiodarone markedly prolongs the QT interval, torsade de pointes is an infrequent complication and is most often reported in association with hypokalemia or with concomitant therapy using a class IA drug, especially quinidine.
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