COMEDK 2007 MCQ Answer 138
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The correct answer is D
Conn syndrome
Conn syndrome
- Primary hyperaldosteronism results from autonomous aldosterone secretion, which, in turn, leads to suppression of renin secretion.
- Primary aldosteronism usually occurs in individuals between the ages of 30 and 50 years and accounts for 1% of cases of hypertension.
- Primary hyperaldosteronism is usually associated with hypokalemia; however, more patients with Conn's syndrome are being diagnosed with normal potassium levels.
- Most cases result from a solitary functioning adrenal adenoma (approximately 70%) and idiopathic bilateral hyperplasia (30%).
- Adrenocortical carcinoma and glucocorticoid suppressible hyperaldosteronism are rare, each accounting for less than 1% of cases.
- Patients typically present with hypertension, which is longstanding, moderate to severe, and may be difficult to control despite multiple-drug therapy.
- Other symptoms include muscle weakness, polydipsia, polyuria, nocturia, headaches, and fatigue.
- Weakness and fatigue are related to the presence of hypokalemia.
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