COMEDK 2007 MCQ Answer 13
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The correct answer is C
Von Willebrand Factor (vWF) is a heterogeneous multimeric glycoprotein which is produced by endothelial cells and megakaryocytes. The molecular weight varies from 400 kD to 20,000 kD. In platelets, vWF is stored in the alpha-granules. In endothelial cells vWF is stored in so-called Weibel-Palade bodies. The normal function of vWF is to stabilize factor VIII, as well as to be a carrier protein of factor VIII. Large vWF multimers also stabilise platelet adhesion to the subendothelial matrix in case of tissue injury.
Von Willebrand Factor (vWF) is a heterogeneous multimeric glycoprotein which is produced by endothelial cells and megakaryocytes. The molecular weight varies from 400 kD to 20,000 kD. In platelets, vWF is stored in the alpha-granules. In endothelial cells vWF is stored in so-called Weibel-Palade bodies. The normal function of vWF is to stabilize factor VIII, as well as to be a carrier protein of factor VIII. Large vWF multimers also stabilise platelet adhesion to the subendothelial matrix in case of tissue injury.
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