COMEDK 2007 MCQ Answer 128
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The correct answer is B
The main drug in the carbapenam class is a drug called IMIPENEM – this drug has excellent, quite broad antimicrobial activity against both g+ and g- organisms, anaerobes, and Psuedomonas infections; it is given with a molecule called cilastatin, which is an inhibitor of the renal enzyme dehydropeptidase – this renal enzyme would otherwise break down the drug too quickly, and would make the drug ineffective in the treatment of UTI’s – thus by giving imipenem with the cilastatin, the half life of the drug is prolonged and it can be used to treat UTI’s.
The main drug in the carbapenam class is a drug called IMIPENEM – this drug has excellent, quite broad antimicrobial activity against both g+ and g- organisms, anaerobes, and Psuedomonas infections; it is given with a molecule called cilastatin, which is an inhibitor of the renal enzyme dehydropeptidase – this renal enzyme would otherwise break down the drug too quickly, and would make the drug ineffective in the treatment of UTI’s – thus by giving imipenem with the cilastatin, the half life of the drug is prolonged and it can be used to treat UTI’s.
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