COMEDK 2007 MCQ Answer 165
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The neuromuscular blockade by the classic pathway (depolarizing), begins when a drug binds to the a subunit of the nicotinic receptors like the molecule of AcetylCholinesterase does. In the beginning, an initial opening of the ion channel produces a contraction (fasciculation). After this, the depolarization of muscular membrane is sustained (persistent depolarization), since the drug is not broken by acetylcholinesterase, leading to neuromuscular block.
The neuromuscular blockade by the classic pathway (depolarizing), begins when a drug binds to the a subunit of the nicotinic receptors like the molecule of AcetylCholinesterase does. In the beginning, an initial opening of the ion channel produces a contraction (fasciculation). After this, the depolarization of muscular membrane is sustained (persistent depolarization), since the drug is not broken by acetylcholinesterase, leading to neuromuscular block.
Tags: Neuromuscular block
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