Answer to Pathology MCQ 152
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IgA NEPHROPATHY
General: a.k.a Berger Disease. Causes: Nephrotic syndrome
Epidemiology/At risk individuals: Most common type of GN worldwide, occurs 1-2 days after URTI/GIT infections in patients
Clinical features / course: There is an acquired or genetic defect in regulating production of IgA antibodies. After URTI / GIT infection, too much IgA is produced à forms immune complexes à trapped in mesangium à elicit alternate complement pathway à injury. Proteinuria + haematuria (Nephrotic syndrome). Progress to ESRF in 25-50% of patients.
Morphology: LM: mesangial proliferation, matrix deposition. IF: IgA in mesangium + C3.
Treatment: none.Category: Pathology MCQs
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