MCQ MAHE 2000 Medicine Answer 12
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In 1948, Wolff and Chaikoff published a landmark paper (1), on the thyroid effect of increasing amounts of iodide (Potassium salt), injected intraperitoneally in rats. The authors stated: Organic binding of iodine within the glands can be almost completely blocked by raising the level of plasma inorganic iodine (PII) above a certain critical level, which for the rat amounts to about 20 to 35 percent. This effect became known as the Wolff-Chaikoff (W-C) Effect.
What is its therapeutic implications?
- it should decrease Iodide uptake by hyperthyroid patients and hence decrease production of T hormones.
- along with that it also reduces the vasularity of the gland, thus decreasing the complication of post-operative bleeding.
- also this wolff-chaikoff effect is transient, and thyroid gland eventually overcomes after a few weeks, therefore it is reserved for pre-operative use!
Tags: MCQ, surgery, Medicine, Wolff-Chaikoff
Category: MAHE 2000 MCQs
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