The Correct Answer is C
The porphyrias are inherited or acquired by disorders of certain enzymes in the heme biosynthetic pathway (also called porphyrin pathway).
Ferrochelatase is an enzyme involved in the eighth step of porphyrin metabolism, converting protoporphyrin IX into heme. Ferrochelatase is inhibited by lead.
The delta -aminolevulinic acid (pronounce) synthase (ALA synthase) reaction occurs in the mitochondria. An essential cofactor is pyridoxal phosphate (vitamin B-6).
Protoporphyrinogen IX oxidase converts the methylene bridges between the pyrrole rings to methenyl bridges in the mitochondrium.
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MAHE 2000 MCQs
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