MCQ MAHE 2000 Pediatrics Answer 07
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- Mongolian spot refers to a macular blue-gray pigmentation usually on the sacral area of healthy infants.
- It is usually present at birth or appears within the first weeks of life.
- It typically disappears spontaneously within 4 years but can persist for life.
- Mongolian spots are observed in more than 90% of infants of the Mongoloid race (ie, East Asians, Indonesians, Polynesians, Micronesians, Amerindians, Eskimos).
- The Mongolian spot is a congenital, developmental condition exclusively involving the skin. It results from entrapment of melanocytes in the dermis during their migration from the neural crest into the epidermis. This migration is regulated by exogenous peptide growth factors that work by the activation of tyrosine kinase receptors. It is postulated that accumulated metabolites such as GM1 and heparan sulfate bind to this tyrosine kinase receptor and lead to severe neurologic manifestations and aberrant neural crest migration.
Tags: MCQ, Mongolian spots, Dermatology, Pediatrics
Category: MAHE 2000 MCQs
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