Retinal Detachment

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Retinal Pigment Epithelium and Macular Diseases (Documenta Ophthalmologica Proceedings Series)The correct option is D


The retinal pigment epithelium (RPE) forms a single layer of about 5 million epithelial cells in the eye. These cells are cubical near the fovea and flatter toward the periphery. The pigment epithelial cells do not undergo mitosis and they have a high metabolic activity and high membrane transport activity. Dead cells have their places occupied by their neighbors expanding in size.

Each pigment epithelium cell is in contact with up to 45 photoreceptors and the pigment epithelium cells are tightly packed close to each other with the cell membranes of neighboring cells attached to each other. These cells therefore prevent the exchange of material between the highly vascular choroid and the nervous tissues (the blood-retina barrier). However no anatomical connection binds the RPE to the photoreceptor layer and therefore it is relatively easy for these two layers to become detached in inauspicious conditions.

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