Hematology MCQ Answer 03
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A deficiency of the intrinsic pathway or contact factors will result in a prolonged APTT that will show a correction to within the APTT reference range upon addition of 50% normal pooled plasma. If the PT is normal, then a prolonged APTT that shows a correction with a mixing study is due to a deficiency of factors VIII, IX, XI, or those of the contact system.
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