General Pharmacology MCQ Answer 003
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- For acidic drugs, the more alkaline the urine, the greater the renal clearance and vice versa for basic drugs, since:
AH = A- + H+
and
B + H+ = BH+
Thus high pH (alkaline conditions) favours A-, the charged form of the weak acid which remains in the tubular fluid and is excreted in the urine, while low pH (acid conditions) favors BH+, the charged form of the base. This is made use of in treating overdose with aspirin (a weak acid) by causing an alkaline urine, thereby accelerating elimination of salicylate.
Category: Pharmacology MCQs
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