Chromosome Eleven
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![The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together [An article from: DNA Repair]](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vMP7IpeQqPH3xqvaEPpC7PHLb06UQczV1HjMRgnbbFEp0x6BSXffJxei-knrT4-QY59ZDR3ScPHGz7ust2eevIBJqUuEjZuaKDchkpeoCY1vImIB6oYirFVdamTU1Q3etaKk0ex297AXivtgd6QCbEp4_nvWTrX44o1UBgANZAGzsF1CCZ0_BZjxjpsRgQWXdawfN6LdpPShhYOnI-6GPCYEqIjbbLdnSPJtGuJ_w=s0-d)
Hyperparathyroidism is associated only with MEN Type I (major) and MEN Type IIA (minor). 85% of patients with MEN Type I have clinically moderate-severe hyperparathyroidism, 35% have Zollinger-Ellison Syndrome, 
and 25% have prolactinomas. MEN I is autosomal dominant and is associated with a defect in the MEN1 gene (a tumor suppressor gene) on Chromosome 11.
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