Chromosome Eleven
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![The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together [An article from: DNA Repair]](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tAV-cX8tc6u93gH9ekI07a4HtyLdv-IybG9h5pB8bzSgVBJkeACCv57U9pa4yoAt39ga1jMP-wc6NXEjo-2RL1A6F6cGtOxJGoysJWZ22nFTbVGYLHjxGx2zlCfrQ7a2V08mQeRgnkMLsJ_GmLAhlM60vwKr7sZlNVhgIU--y43yEVZ4RQdWFwFfsbnFf9y70lZvByEUQqPGNrWdfzwgm9vI0zKcGWVl0v6ztQ4fg=s0-d)
Hyperparathyroidism is associated only with MEN Type I (major) and MEN Type IIA (minor). 85% of patients with MEN Type I have clinically moderate-severe hyperparathyroidism, 35% have Zollinger-Ellison Syndrome, 
and 25% have prolactinomas. MEN I is autosomal dominant and is associated with a defect in the MEN1 gene (a tumor suppressor gene) on Chromosome 11.
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