Chromosome Eleven
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![The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together [An article from: DNA Repair]](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_seWCgAosssM6F7LdMxlZr5OHhEP9krlo8Kqo3vgDTpEkVsqOBQWqq3xus_wGDoVD-AkSRQy63z_3Syaj1Zj6P4FenP-VHQikQJwhqY355s0KH4QEAxEaIsTiN2RpsvQdbW1qRQhq_eHMvDkzbBIc_zaxbpy-P-WZMvTovuXdnDOhNlhbm80I8d71ZvV-DLlR90wVCNeuCop2qIu7DMwkI5gSL_v5X4CFrPLHQ43kQ=s0-d)
Hyperparathyroidism is associated only with MEN Type I (major) and MEN Type IIA (minor). 85% of patients with MEN Type I have clinically moderate-severe hyperparathyroidism, 35% have Zollinger-Ellison Syndrome, 
and 25% have prolactinomas. MEN I is autosomal dominant and is associated with a defect in the MEN1 gene (a tumor suppressor gene) on Chromosome 11.
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